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Dnmt1 Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality

Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation of the imprinted region. We have compared the intrinsic susceptibilities of the imprinted region of Ig...

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Publicado no:Mol Cell Biol
Principais autores: Biniszkiewicz, Detlev, Gribnau, Joost, Ramsahoye, Bernard, Gaudet, François, Eggan, Kevin, Humpherys, David, Mastrangelo, Mary-Ann, Jun, Zhan, Walter, Jörn, Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2002
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133685/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884600/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.7.2124-2135.2002
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