Dnmt1 Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality

Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation of the imprinted region. We have compared the intrinsic susceptibilities of the imprinted region of Ig...

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Detalhes bibliográficos
Main Authors: Biniszkiewicz, Detlev, Gribnau, Joost, Ramsahoye, Bernard, Gaudet, François, Eggan, Kevin, Humpherys, David, Mastrangelo, Mary-Ann, Jun, Zhan, Walter, Jörn, Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133685/
https://ncbi.nlm.nih.gov/pubmed/11884600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.7.2124-2135.2002
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