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Loss of CpG island immunity to DNA methylation induced by mutation

Abstract The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715–731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI) can induce DNA methylation of the CGI and that this aberrant methylation pattern...

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Principais autores: Bernhard Horsthemke, Adrian Bird
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2023-05-01
סדרה:Epigenetics & Chromatin
נושאים:
Epigenetics
DNA methylation
CpG island
Transgenerational inheritance
Acquired characters
Mutation
גישה מקוונת:https://doi.org/10.1186/s13072-023-00488-5
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