Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas

BACKGROUND: Alteration of DNA methylation of tumor suppressor genes (TSGs) is one of the most consistent epigenetic changes in human cancers. DNMTs play several important roles in DNA methylation and development of cancers. Regarding DNMTs protein expressions, little is known about the clinical sign...

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Detalhes bibliográficos
Publicado no:Med Sci Monit
Main Authors: Ma, Hou-Shi, Wang, Elaine Lu, Xu, Wen-Fei, Yamada, Shozo, Yoshimoto, Katsuhiko, Qian, Zhi Rong, Shi, Long, Liu, Li-Li, Li, Xu-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2018
Assuntos:
Lab/In Vitro Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069575/
https://ncbi.nlm.nih.gov/pubmed/30002361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.910608
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