Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock Induced Liver Injury

Hemorrhagic shock (HS) is a life-threatening condition associated with tissue hypoperfusion, and often leads to injury of multiple organs including the liver. Pregnane X receptor (PXR) is a species-specific xenobiotic receptor that regulates the expression of drug-metabolizing enzymes (DMEs) such as...

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Udgivet i:Hepatology
Main Authors: Xie, Yang, Xu, Meishu, Deng, Meihong, Li, Zhigang, Wang, Pengcheng, Ren, Songrong, Guo, Yan, Ma, Xiaochao, Fan, Jie, Billiar, Timothy R., Xie, Wen
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717545/
https://ncbi.nlm.nih.gov/pubmed/31038762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30691
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