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Chronic Activation of Liver X Receptor Sensitizes Mice to High Cholesterol Diet–Induced Gut Toxicity

Cholesterol is essential for numerous biologic functions and processes, but an excess of intracellular cholesterol can be toxic. Intestinal cholesterol absorption is a major determinant of plasma cholesterol level. The liver X receptor (LXR) is a nuclear receptor known for its activity in cholestero...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: Garbacz, Wojciech G., Uppal, Hirdesh, Yan, Jiong, Xu, Meishu, Ren, Songrong, Stolz, Donna B., Huang, Min, Xie, Wen
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108576/
https://ncbi.nlm.nih.gov/pubmed/30045953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112672
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