An Unexpected Role of Cholesterol Sulfotransferase and its Regulation in Sensitizing Mice to Acetaminophen-Induced Liver Injury

Overdose of acetaminophen (APAP) is the leading cause of acute liver failure (ALF) in the United States. The sulfotransferase-mediated sulfation of APAP is widely believed to be a protective mechanism to attenuate the hepatotoxicity of APAP. The cholesterol sulfotransferase SULT2B1b is best known fo...

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Publicat a:Mol Pharmacol
Autors principals: An, Yunqi, Wang, Pengcheng, Xu, Pengfei, Tung, Hung-Chun, Xie, Yang, Kirisci, Levent, Xu, Meishu, Ren, Songrong, Tian, Xin, Ma, Xiaochao, Xie, Wen
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491915/
https://ncbi.nlm.nih.gov/pubmed/30944208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.114819
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