Pregnane X Receptor as a Therapeutic Target to Inhibit Androgen Activity

The androgen-androgen receptor signaling pathway plays an important role in the pathogenesis of prostate cancer. Accordingly, androgen deprivation has been the most effective endocrine therapy for hormone-dependent prostate cancer. Here, we report a novel pregnane X receptor (PXR)-mediated and metab...

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Autori principali: Zhang, Bin, Cheng, Qiuqiong, Ou, Zhimin, Lee, Jung Hoon, Xu, Meishu, Kochhar, Upasana, Ren, Songrong, Huang, Min, Pflug, Beth R., Xie, Wen
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Endocrine Society 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999492/
https://ncbi.nlm.nih.gov/pubmed/20962047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0708
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