A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells

The cell-cell adhesion protein E-cadherin (CDH1) is a tumor suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer (DGC) and lobular breast cancer (LBC). In addition, germline mutations in CDH1...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Beetham, Henry, Chen, Augustine, Telford, Bryony J., Single, Andrew, Jarman, Kate E., Lackovic, Kurt, Luxenburger, Andreas, Guilford, Parry
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715681/
https://ncbi.nlm.nih.gov/pubmed/31467357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48929-0
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