E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

BACKGROUND: The E-cadherin gene (CDH1) is frequently mutated in diffuse gastric cancer and lobular breast cancer, and germline mutations predispose to the cancer syndrome Hereditary Diffuse Gastric Cancer. We are taking a synthetic lethal approach to identify druggable vulnerabilities in CDH1-mutant...

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Publicado en:Gastric Cancer
Main Authors: Godwin, Tanis D., Kelly, S. Thomas, Brew, Tom P., Bougen-Zhukov, Nicola M., Single, Andrew B., Chen, Augustine, Stylianou, Cassie E., Harris, Lawrence D., Currie, Sophie K., Telford, Bryony J., Beetham, Henry G., Evans, Gary B., Black, Michael A., Guilford, Parry J.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Singapore 2018
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6394693/
https://ncbi.nlm.nih.gov/pubmed/30066183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10120-018-0859-1
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