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A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells

The cell-cell adhesion protein E-cadherin (CDH1) is a tumor suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer (DGC) and lobular breast cancer (LBC). In addition, germline mutations in CDH1...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Beetham, Henry, Chen, Augustine, Telford, Bryony J., Single, Andrew, Jarman, Kate E., Lackovic, Kurt, Luxenburger, Andreas, Guilford, Parry
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715681/
https://ncbi.nlm.nih.gov/pubmed/31467357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48929-0
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