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The X-linked histone demethylase Kdm6a in CD4(+) T lymphocytes modulates autoimmunity

Multiple sclerosis (MS) is a putative T cell–mediated autoimmune disease. As with many autoimmune diseases, females are more susceptible than males. Sexual dimorphisms may be due to differences in sex hormones, sex chromosomes, or both. Regarding sex chromosome genes, a small percentage of X chromos...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Itoh, Yuichiro, Golden, Lisa C., Itoh, Noriko, Matsukawa, Macy Akiyo, Ren, Emily, Tse, Vincent, Arnold, Arthur P., Voskuhl, Rhonda R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715385/
https://ncbi.nlm.nih.gov/pubmed/31403472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126250
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