An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). We demonstrated that conditional inactivation of Pml in the mouse prostate morphs indolent Pten-null tumors int...

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Pubblicato in:Nat Genet
Autori principali: Chen, Ming, Zhang, Jiangwen, Sampieri, Katia, Clohessy, John G., Mendez, Lourdes, Gonzalez-Billalabeitia, Enrique, Liu, Xue-Song, Lee, Yu-Ru, Fung, Jacqueline, Katon, Jesse M., Menon, Archita Venugopal, Webster, Kaitlyn A., Ng, Christopher, Palumbieri, Maria Dilia, Diolombi, Moussa S., Breitkopf, Susanne B., Teruya-Feldstein, Julie, Signoretti, Sabina, Bronson, Roderick T., Asara, John M., Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714980/
https://ncbi.nlm.nih.gov/pubmed/29335545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-017-0027-2
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