Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

Diacylglycerol kinases (DGKs) transform diacylglycerol (DAG) into phosphatidic acid (PA), balancing the levels of these key metabolic and signaling lipids. We previously showed that PA derived from the DGKζ isoform promotes mammalian target of rapamycin complex 1 (mTORC1) activation. This function m...

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Detalles Bibliográficos
Publicado en:Oncogenesis
Main Authors: Torres-Ayuso, P, Tello-Lafoz, M, Mérida, I, Ávila-Flores, A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632073/
https://ncbi.nlm.nih.gov/pubmed/26302180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2015.22
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