Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

Diacylglycerol kinases (DGKs) transform diacylglycerol (DAG) into phosphatidic acid (PA), balancing the levels of these key metabolic and signaling lipids. We previously showed that PA derived from the DGKζ isoform promotes mammalian target of rapamycin complex 1 (mTORC1) activation. This function m...

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Bibliographic Details
Published in:Oncogenesis
Main Authors: Torres-Ayuso, P, Tello-Lafoz, M, Mérida, I, Ávila-Flores, A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632073/
https://ncbi.nlm.nih.gov/pubmed/26302180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2015.22
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