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mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity
Protein kinase Cζ (PKCζ) is phosphorylated at the activation loop and the turn motif (TM). However, the TM kinase and functional relevance of TM phosphorylation remain largely unknown. We demonstrate that PKCζ TM is phosphorylated directly by the mTORC2 complex, and this phosphorylation is required...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989865/ https://ncbi.nlm.nih.gov/pubmed/24375676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338119 |
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