Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis

Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting the mouse orthologs of human DOK2 and DUSP4 genes, which were co-deleted in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Chen, Ming, Zhang, Jiangwen, Berger, Alice H., Diolombi, Moussa S., Ng, Christopher, Fung, Jacqueline, Bronson, Roderick T., Castillo-Martin, Mireia, Thin, Tin Htwe, Cordon-Cardo, Carlos, Plevin, Robin, Pandolfi, Pier Paolo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307955/
https://ncbi.nlm.nih.gov/pubmed/30475228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99699
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