Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis

Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting the mouse orthologs of human DOK2 and DUSP4 genes, which were co-deleted in...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Chen, Ming, Zhang, Jiangwen, Berger, Alice H., Diolombi, Moussa S., Ng, Christopher, Fung, Jacqueline, Bronson, Roderick T., Castillo-Martin, Mireia, Thin, Tin Htwe, Cordon-Cardo, Carlos, Plevin, Robin, Pandolfi, Pier Paolo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307955/
https://ncbi.nlm.nih.gov/pubmed/30475228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99699
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