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Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting the mouse orthologs of human DOK2 and DUSP4 genes, which were co-deleted in...
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| Udgivet i: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6307955/ https://ncbi.nlm.nih.gov/pubmed/30475228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99699 |
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