Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis

Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting the mouse orthologs of human DOK2 and DUSP4 genes, which were co-deleted in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Chen, Ming, Zhang, Jiangwen, Berger, Alice H., Diolombi, Moussa S., Ng, Christopher, Fung, Jacqueline, Bronson, Roderick T., Castillo-Martin, Mireia, Thin, Tin Htwe, Cordon-Cardo, Carlos, Plevin, Robin, Pandolfi, Pier Paolo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307955/
https://ncbi.nlm.nih.gov/pubmed/30475228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99699
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