Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis

Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting the mouse orthologs of human DOK2 and DUSP4 genes, which were co-deleted in...

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Vydáno v:J Clin Invest
Hlavní autoři: Chen, Ming, Zhang, Jiangwen, Berger, Alice H., Diolombi, Moussa S., Ng, Christopher, Fung, Jacqueline, Bronson, Roderick T., Castillo-Martin, Mireia, Thin, Tin Htwe, Cordon-Cardo, Carlos, Plevin, Robin, Pandolfi, Pier Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307955/
https://ncbi.nlm.nih.gov/pubmed/30475228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99699
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