The Renal Elimination Pathways of the Dabigatran Reversal Agent Idarucizumab and its Impact on Dabigatran Elimination

Idarucizumab, a humanized monoclonal antibody fragment (Fab), provides rapid and sustained reversal of dabigatran-mediated anticoagulation. Idarucizumab and dabigatran are mainly eliminated via the kidneys. This analysis aimed to characterize the renal elimination of idarucizumab and investigate the...

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Publicado en:Clin Appl Thromb Hemost
Autores principales: Glund, Stephan, Gan, Guanfa, Moschetti, Viktoria, Reilly, Paul, Honickel, Markus, Grottke, Oliver, Van Ryn, Joanne
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE Publications 2018
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714879/
https://ncbi.nlm.nih.gov/pubmed/29534609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1076029618755947
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