Evaluation of the immunogenicity of the dabigatran reversal agent idarucizumab during Phase I studies

AIMS: Idarucizumab, a humanized monoclonal anti‐dabigatran antibody fragment, is effective in emergency reversal of dabigatran anticoagulation. Pre‐existing and treatment‐emergent anti‐idarucizumab antibodies (antidrug antibodies; ADA) may affect the safety and efficacy of idarucizumab. This analysi...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Norris, Stephen, Ramael, Steven, Ikushima, Ippei, Haazen, Wouter, Harada, Akiko, Moschetti, Viktoria, Imazu, Susumu, Reilly, Paul A., Lang, Benjamin, Stangier, Joachim, Glund, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Drug Safety
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510069/
https://ncbi.nlm.nih.gov/pubmed/28230262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13269
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