Pharmacokinetics of idarucizumab and its target dabigatran in patients requiring urgent reversal of the anticoagulant effect of dabigatran

BACKGROUND: Idarucizumab is a monoclonal antibody fragment that reverses dabigatran anticoagulation. Pharmacokinetics (PK) of idarucizumab have been described in healthy, elderly, or renally impaired (RI) volunteers, but PK data in patients are lacking. OBJECTIVES: This analysis describes the PK of...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Glund, Stephan, Coble, Kelly, Gansser, Dietmar, Stangier, Joachim, Hoermann, Karin, Pollack, Charles V., Reilly, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
CLINICAL HAEMOSTASIS AND THROMBOSIS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6852568/
https://ncbi.nlm.nih.gov/pubmed/31050868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14476
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