Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of convertase bound FP. A structural core formed...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Pedersen, Dennis V., Gadeberg, Trine A. F., Thomas, Caroline, Wang, Yong, Joram, Nicolas, Jensen, Rasmus K., Mazarakis, Sofia M. M., Revel, Margot, El Sissy, Carine, Petersen, Steen V., Lindorff-Larsen, Kresten, Thiel, Steffen, Laursen, Nick S., Fremeaux-Bacchi, Véronique, Andersen, Gregers R.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713926/
https://ncbi.nlm.nih.gov/pubmed/31507604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02007
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