Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

Target of rapamycin complex 1 (TORC1) and AMP-activated protein kinase (AMPK) antagonistically modulate metabolism and aging. However, how they coordinate to determine longevity and if they act via separable mechanisms is unclear. Here, we show that neuronal AMPK is essential for lifespan extension...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zhang, Yue, Lanjuin, Anne, Chowdhury, Suvagata Roy, Mistry, Meeta, Silva-García, Carlos G, Weir, Heather J, Lee, Chia-Lin, Escoubas, Caroline C, Tabakovic, Emina, Mair, William B
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713509/
https://ncbi.nlm.nih.gov/pubmed/31411562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49158
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