Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

Target of rapamycin complex 1 (TORC1) and AMP-activated protein kinase (AMPK) antagonistically modulate metabolism and aging. However, how they coordinate to determine longevity and if they act via separable mechanisms is unclear. Here, we show that neuronal AMPK is essential for lifespan extension...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Zhang, Yue, Lanjuin, Anne, Chowdhury, Suvagata Roy, Mistry, Meeta, Silva-García, Carlos G, Weir, Heather J, Lee, Chia-Lin, Escoubas, Caroline C, Tabakovic, Emina, Mair, William B
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Genetics and Genomics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713509/
https://ncbi.nlm.nih.gov/pubmed/31411562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49158
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