Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans

Mild inhibition of mitochondrial respiration extends the lifespan of many species. In Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-inducible factor 1 (HIF-1) in response to reduced mitochondrial respiration. However, the physiological role and mechani...

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Hlavní autoři: Hwang, Ara B., Ryu, Eun-A, Artan, Murat, Chang, Hsin-Wen, Kabir, Mohammad Humayun, Nam, Hyun-Jun, Lee, Dongyeop, Yang, Jae-Seong, Kim, Sanguk, Mair, William B., Lee, Cheolju, Lee, Siu Sylvia, Lee, Seung-Jae
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210294/
https://ncbi.nlm.nih.gov/pubmed/25288734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411199111
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