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Inhibition of elongin C promotes longevity and protein homeostasis via HIF‐1 in C. elegans
The transcription factor hypoxia‐inducible factor 1 (HIF‐1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans. We previously performed a genomewide RNA interference screen and identified many genes that act as potential negative regulators of HIF‐1. Here, we fun...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4693473/ https://ncbi.nlm.nih.gov/pubmed/26361075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12390 |
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