RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we...

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Publicado no:Nat Commun
Main Authors: Son, Heehwa G., Seo, Mihwa, Ham, Seokjin, Hwang, Wooseon, Lee, Dongyeop, An, Seon Woo A., Artan, Murat, Seo, Keunhee, Kaletsky, Rachel, Arey, Rachel N., Ryu, Youngjae, Ha, Chang Man, Kim, Yoon Ki, Murphy, Coleen T., Roh, Tae-Young, Nam, Hong Gil, Lee, Seung-Jae V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347137/
https://ncbi.nlm.nih.gov/pubmed/28276441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14749
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