Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Son, Heehwa G., Seo, Keunhee, Seo, Mihwa, Park, Sangsoon, Ham, Seokjin, An, Seon Woo A., Choi, Eun-Seok, Lee, Yujin, Baek, Haeshim, Kim, Eunju, Ryu, Youngjae, Ha, Chang Man, Hsu, Ao-Lin, Roh, Tae-Young, Jang, Sung Key, Lee, Seung-Jae V.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295163/
https://ncbi.nlm.nih.gov/pubmed/30478249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.317362.118
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