RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans

The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Seo, Mihwa, Seo, Keunhee, Hwang, Wooseon, Koo, Hee Jung, Hahm, Jeong-Hoon, Yang, Jae-Seong, Han, Seong Kyu, Hwang, Daehee, Kim, Sanguk, Jang, Sung Key, Lee, Yoontae, Nam, Hong Gil, Lee, Seung-Jae V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534234/
https://ncbi.nlm.nih.gov/pubmed/26195740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505451112
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