Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans

FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling....

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Chen, Albert Tzong-Yang, Guo, Chunfang, Itani, Omar A., Budaitis, Breane G., Williams, Travis W., Hopkins, Christopher E., McEachin, Richard C., Pande, Manjusha, Grant, Ana R., Yoshina, Sawako, Mitani, Shohei, Hu, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2015
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596673/
https://ncbi.nlm.nih.gov/pubmed/26219299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.177998
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