Splicing Factor 1 Modulates Dietary Restriction and TORC1 Pathway Longevity in C. elegans

Ageing is driven by a loss of transcriptional and protein homeostasis(1–3) and is the key risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic dysfunction seen with age therefore have potential to reduce overall disease risk in the elderly. Pre-mRNA splicing is...

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Publicado no:Nature
Main Authors: Heintz, Caroline, Doktor, Thomas Koed, Lanjuin, Anne, Escoubas, Caroline, Zhang, Yue, Weir, Heather J., Dutta, Sneha, Silva-García, Carlos Giovanni, Bruun, Gitte Hoffmann, Morantte, Ianessa, Hoxhaj, Gerta, Manning, Brendan D., Andresen, Brage S., Mair, William B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361225/
https://ncbi.nlm.nih.gov/pubmed/27919065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20789
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