CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans

The mechanistic target of rapamycin (mTOR) kinase is central to metabolism and growth, and has a conserved role in aging. mTOR functions in two complexes, mTORC1 and mTORC2. In diverse eukaryotes, inhibition of mTORC1 signaling increases lifespan. mTORC1 transduces anabolic signals to stimulate prot...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Li, Yujie, Finkbeiner, Sandra, Ganner, Athina, Gerber, Julia, Klein, Marinella, Grafe, Manuel, Kandzia, Jakob, Thien, Antje, Thedieck, Kathrin, Breves, Gerhard, Jank, Thomas, Baumeister, Ralf, Walz, Gerd, Neumann-Haefelin, Elke
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2018
Assuntos:
Research Paper: Gerotarget(Focus on Aging)
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839386/
https://ncbi.nlm.nih.gov/pubmed/29515755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24039
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