CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans

The mechanistic target of rapamycin (mTOR) kinase is central to metabolism and growth, and has a conserved role in aging. mTOR functions in two complexes, mTORC1 and mTORC2. In diverse eukaryotes, inhibition of mTORC1 signaling increases lifespan. mTORC1 transduces anabolic signals to stimulate prot...

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Vydáno v:Oncotarget
Hlavní autoři: Li, Yujie, Finkbeiner, Sandra, Ganner, Athina, Gerber, Julia, Klein, Marinella, Grafe, Manuel, Kandzia, Jakob, Thien, Antje, Thedieck, Kathrin, Breves, Gerhard, Jank, Thomas, Baumeister, Ralf, Walz, Gerd, Neumann-Haefelin, Elke
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper: Gerotarget(Focus on Aging)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839386/
https://ncbi.nlm.nih.gov/pubmed/29515755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24039
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