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mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

The nematode worm Caenorhabditis elegans provides a powerful system for elucidating how genetic, metabolic, nutritional, and environmental factors influence aging. The mechanistic target of rapamycin (mTOR) kinase is important in growth, disease, and aging and is present in the mTORC1 and mTORC2 com...

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Autors principals: Mizunuma, Masaki, Neumann-Haefelin, Elke, Moroz, Natalie, Li, Yujie, Blackwell, T Keith
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172656/
https://ncbi.nlm.nih.gov/pubmed/25040785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12248
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