VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma

Inactivation of the tumor suppressor von Hippel–Lindau (VHL) gene is a key event in hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The mechanistic target of rapamycin (mTOR) signaling pathway is a fundamental regulator of cell growth and proliferation, and hyperactivation of mTOR...

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Pubblicato in:Sci Rep
Autori principali: Ganner, Athina, Gehrke, Christina, Klein, Marinella, Thegtmeier, Lena, Matulenski, Tanja, Wingendorf, Laura, Wang, Lu, Pilz, Felicitas, Greidl, Lars, Meid, Lisa, Kotsis, Fruzsina, Walz, Gerd, Frew, Ian J., Neumann-Haefelin, Elke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295262/
https://ncbi.nlm.nih.gov/pubmed/34290272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94132-5
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