Helicase-like transcription factor (Hltf) gene-deletion promotes oxidative phosphorylation (OXPHOS) in colorectal tumors of AOM/DSS-treated mice

The helicase-like transcription factor (HLTF) gene—a tumor suppressor in human colorectal cancer (CRC)—is regulated by alternative splicing and promoter hypermethylation. In this study, we used the AOM/DSS-induced mouse model to show Hltf-deletion caused poor survival concomitant with increased tumo...

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Publicado en:PLoS One
Autores principales: Helmer, Rebecca A., Kaur, Gurvinder, Smith, Lisa A., Chilton, Beverly S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713344/
https://ncbi.nlm.nih.gov/pubmed/31461471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221751
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