Phase Ib Trial To Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of Filociclovir (MBX-400, Cyclopropavir) in Healthy Volunteers

Filociclovir (MBX-400, cyclopropavir) is an antiviral agent with activity against cytomegalovirus (CMV). A phase 1, double-blind, randomized, placebo-controlled (3:1 ratio), single-center, multiple-ascending-dose trial was conducted to assess the safety, tolerability, and pharmacokinetics of filocic...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Rouphael, Nadine G., Hurwitz, Selwyn J., Hart, Mari, Beck, Allison, Anderson, Evan J., Deye, Gregory, Osborn, Blaire, Cai, Shu Yi, Focht, Chris, Amegashie, Cyrille, Bowlin, Terry L., Brooks, Jennifer, Mulligan, Mark J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709474/
https://ncbi.nlm.nih.gov/pubmed/31285228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00717-19
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