Phase Ib Trial To Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of Filociclovir (MBX-400, Cyclopropavir) in Healthy Volunteers

Filociclovir (MBX-400, cyclopropavir) is an antiviral agent with activity against cytomegalovirus (CMV). A phase 1, double-blind, randomized, placebo-controlled (3:1 ratio), single-center, multiple-ascending-dose trial was conducted to assess the safety, tolerability, and pharmacokinetics of filocic...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Rouphael, Nadine G., Hurwitz, Selwyn J., Hart, Mari, Beck, Allison, Anderson, Evan J., Deye, Gregory, Osborn, Blaire, Cai, Shu Yi, Focht, Chris, Amegashie, Cyrille, Bowlin, Terry L., Brooks, Jennifer, Mulligan, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709474/
https://ncbi.nlm.nih.gov/pubmed/31285228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00717-19
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