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SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin‐deficient mice

The sarco/endoplasmic reticulum Ca(2+)‐ATPase (SERCA) is imperative for normal cardiac function regulating both muscle relaxation and contractility. SERCA2a is the predominant isoform in cardiac muscles and is inhibited by phospholamban (PLN). Under conditions of oxidative stress, SERCA2a may also b...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Braun, Jessica L., Hamstra, Sophie I., Messner, Holt N., Fajardo, Val A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708055/
https://ncbi.nlm.nih.gov/pubmed/31444868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14215
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