Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain

Accumulating evidence suggests that the copper-binding amyloid precursor protein (APP) has an essential synaptic function. APP synaptogenic function depends on trans-directed dimerization of the extracellular E1 domain encompassing a growth factor-like domain (GFLD) and a copper-binding domain (CuBD...

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Publicat a:J Neurosci
Autors principals: Baumkötter, Frederik, Schmidt, Nadine, Vargas, Carolyn, Schilling, Sandra, Weber, Rebecca, Wagner, Katja, Fiedler, Sebastian, Klug, Wilfried, Radzimanowski, Jens, Nickolaus, Sebastian, Keller, Sandro, Eggert, Simone, Wild, Klemens, Kins, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705248/
https://ncbi.nlm.nih.gov/pubmed/25122912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0180-14.2014
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