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Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

Alzheimer’s disease (AD) is ultimately linked to the amyloid precursor protein (APP). However, current research reveals an important synaptic function of APP and APP-like proteins (APLP1 and 2). In this context various neurotrophic and neuroprotective functions have been reported for the APP proteol...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Wild, Klemens, August, Alexander, Pietrzik, Claus U., Kins, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5281630/
https://ncbi.nlm.nih.gov/pubmed/28197076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00021
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