Shedding of APP limits its synaptogenic activity and cell adhesion properties

The amyloid precursor protein (APP) plays a central role in Alzheimer’s disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its extracellular domain. Since neuronal APP is ex...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Stahl, Ronny, Schilling, Sandra, Soba, Peter, Rupp, Carsten, Hartmann, Tobias, Wagner, Katja, Merdes, Gunter, Eggert, Simone, Kins, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253958/
https://ncbi.nlm.nih.gov/pubmed/25520622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00410
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