Shift from Extracellular Signal-Regulated Kinase to AKT/cAMP Response Element-Binding Protein Pathway Increases Survival-Motor-Neuron Expression in Spinal-Muscular-Atrophy-Like Mice and Patient Cells

Spinal muscular atrophy (SMA), a recessive neurodegenerative disease, is characterized by the selective loss of spinal motor neurons. No available therapy exists for SMA, which represents one of the leading genetic causes of death in childhood. SMA is caused by a mutation of the survival-of-motor-ne...

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Udgivet i:J Neurosci
Main Authors: Branchu, Julien, Biondi, Olivier, Chali, Farah, Collin, Thibault, Leroy, Felix, Mamchaoui, Kamel, Makoukji, Joelle, Pariset, Claude, Lopes, Philippe, Massaad, Charbel, Chanoine, Christophe, Charbonnier, Frédéric
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704952/
https://ncbi.nlm.nih.gov/pubmed/23467345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2728-12.2013
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