In Vivo NMDA Receptor Activation Accelerates Motor Unit Maturation, Protects Spinal Motor Neurons, and Enhances SMN2 Gene Expression in Severe Spinal Muscular Atrophy Mice

Spinal muscular atrophy (SMA), a lethal neurodegenerative disease that occurs in childhood, is caused by the misexpression of the survival of motor neuron (SMN) protein in motor neurons. It is still unclear whether activating motor units in SMA corrects the delay in the postnatal maturation of the m...

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Publicado no:J Neurosci
Main Authors: Biondi, Olivier, Branchu, Julien, Sanchez, Gabriel, Lancelin, Camille, Deforges, Séverine, Lopes, Philippe, Pariset, Claude, Lécolle, Sylvie, Côté, Jocelyn, Chanoine, Christophe, Charbonnier, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633349/
https://ncbi.nlm.nih.gov/pubmed/20739549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1764-10.2010
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