Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

Standard therapy of osteosarcoma (OS) and Ewing sarcoma (EW) rests on cytotoxic regimes, which are largely unsuccessful in advanced patients. Preclinical models are needed to break this impasse. A panel of patient-derived xenografts (PDX) was established by implantation of fresh, surgically resected...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Nanni, Patrizia, Landuzzi, Lorena, Manara, Maria Cristina, Righi, Alberto, Nicoletti, Giordano, Cristalli, Camilla, Pasello, Michela, Parra, Alessandro, Carrabotta, Marianna, Ferracin, Manuela, Palladini, Arianna, Ianzano, Marianna L., Giusti, Veronica, Ruzzi, Francesca, Magnani, Mauro, Donati, Davide Maria, Picci, Piero, Lollini, Pier-Luigi, Scotlandi, Katia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704066/
https://ncbi.nlm.nih.gov/pubmed/31434953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48634-y
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