Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

BACKGROUND: Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere with rhabdomyosarcoma growth, no attempt to neutralize IGF2 has been reported....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Cancer
Egile Nagusiak: De Giovanni, Carla, Nanni, Patrizia, Landuzzi, Lorena, Ianzano, Marianna L., Nicoletti, Giordano, Croci, Stefania, Palladini, Arianna, Lollini, Pier-Luigi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367747/
https://ncbi.nlm.nih.gov/pubmed/30732578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5339-4
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