ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

BACKGROUND: The treatment of metastatic osteosarcoma (OS) remains a challenge for oncologists, and novel therapeutic strategies are urgently needed. An understanding of the pathways that regulate OS dissemination is required for the design of novel treatment approaches. We recently identified Rho-as...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zucchini, Cinzia, Manara, Maria Cristina, Cristalli, Camilla, Carrabotta, Marianna, Greco, Sara, Pinca, Rosa Simona, Ferrari, Cristina, Landuzzi, Lorena, Pasello, Michela, Lollini, Pier-Luigi, Gambarotti, Marco, Donati, Davide Maria, Scotlandi, Katia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933701/
https://ncbi.nlm.nih.gov/pubmed/31878963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1506-3
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