ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

BACKGROUND: The treatment of metastatic osteosarcoma (OS) remains a challenge for oncologists, and novel therapeutic strategies are urgently needed. An understanding of the pathways that regulate OS dissemination is required for the design of novel treatment approaches. We recently identified Rho-as...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Zucchini, Cinzia, Manara, Maria Cristina, Cristalli, Camilla, Carrabotta, Marianna, Greco, Sara, Pinca, Rosa Simona, Ferrari, Cristina, Landuzzi, Lorena, Pasello, Michela, Lollini, Pier-Luigi, Gambarotti, Marco, Donati, Davide Maria, Scotlandi, Katia
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933701/
https://ncbi.nlm.nih.gov/pubmed/31878963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1506-3
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