Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

Standard therapy of osteosarcoma (OS) and Ewing sarcoma (EW) rests on cytotoxic regimes, which are largely unsuccessful in advanced patients. Preclinical models are needed to break this impasse. A panel of patient-derived xenografts (PDX) was established by implantation of fresh, surgically resected...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nanni, Patrizia, Landuzzi, Lorena, Manara, Maria Cristina, Righi, Alberto, Nicoletti, Giordano, Cristalli, Camilla, Pasello, Michela, Parra, Alessandro, Carrabotta, Marianna, Ferracin, Manuela, Palladini, Arianna, Ianzano, Marianna L., Giusti, Veronica, Ruzzi, Francesca, Magnani, Mauro, Donati, Davide Maria, Picci, Piero, Lollini, Pier-Luigi, Scotlandi, Katia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704066/
https://ncbi.nlm.nih.gov/pubmed/31434953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48634-y
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