Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

Standard therapy of osteosarcoma (OS) and Ewing sarcoma (EW) rests on cytotoxic regimes, which are largely unsuccessful in advanced patients. Preclinical models are needed to break this impasse. A panel of patient-derived xenografts (PDX) was established by implantation of fresh, surgically resected...

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Publicado en:Sci Rep
Autores principales: Nanni, Patrizia, Landuzzi, Lorena, Manara, Maria Cristina, Righi, Alberto, Nicoletti, Giordano, Cristalli, Camilla, Pasello, Michela, Parra, Alessandro, Carrabotta, Marianna, Ferracin, Manuela, Palladini, Arianna, Ianzano, Marianna L., Giusti, Veronica, Ruzzi, Francesca, Magnani, Mauro, Donati, Davide Maria, Picci, Piero, Lollini, Pier-Luigi, Scotlandi, Katia
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704066/
https://ncbi.nlm.nih.gov/pubmed/31434953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48634-y
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