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Protein amounts of the MYC transcription factor determine germinal center B cell division capacity

High affinity B cell selection in the germinal center (GC) is governed by signals delivered by follicular helper T cells (Tfh) to B cells. Selected B cells undergo clonal expansion and affinity maturation in the GC dark zone in direct proportion to the amount of antigen they capture and present to T...

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Bibliografische gegevens
Gepubliceerd in:Immunity
Hoofdauteurs: Finkin, Shlomo, Hartweger, Harald, Oliveira, Thiago Y., Kara, Ervin E., Nussenzweig, Michel C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703930/
https://ncbi.nlm.nih.gov/pubmed/31350178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.06.013
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