c-MYC is required for germinal center selection and cyclic re-entry

Upon antigenic challenge, B cells enter the dark-zone (DZ) of germinal-centers (GC) to proliferate and hypermutate their immunoglobulin genes. Mutants with increased affinity are positively selected in the light-zone (LZ) to either differentiate into plasma and memory cells, or re-enter the DZ. The...

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Main Authors: Dominguez-Sola, David, Victora, Gabriel D., Ying, Carol Y., Phan, Ryan T., Saito, Masumichi, Nussenzweig, Michel C., Dalla-Favera, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711534/
https://ncbi.nlm.nih.gov/pubmed/23001145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2428
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