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c-MYC is required for germinal center selection and cyclic re-entry
Upon antigenic challenge, B cells enter the dark-zone (DZ) of germinal-centers (GC) to proliferate and hypermutate their immunoglobulin genes. Mutants with increased affinity are positively selected in the light-zone (LZ) to either differentiate into plasma and memory cells, or re-enter the DZ. The...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711534/ https://ncbi.nlm.nih.gov/pubmed/23001145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2428 |
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