Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas

Germinal centers (GCs) are sites of B-cell clonal expansion, hypermutation, and selection. GCs are polarized into dark (DZ) and light zones (LZ), a distinction that is of key importance to GC selection. However, the difference between the B cells in each of these zones in humans remains unclear. We...

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Main Authors: Victora, Gabriel D., Dominguez-Sola, David, Holmes, Antony B., Deroubaix, Stephanie, Dalla-Favera, Riccardo, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2012
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447782/
https://ncbi.nlm.nih.gov/pubmed/22740445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415380
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