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A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center
The germinal center (GC) reaction is essential for the generation of the somatically hypermutated, high-affinity antibodies that mediate adaptive immunity. Entry into the GC is limited to a small number of B cell clones; however, the process by which this limited number of clones is selected is uncl...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173244/ https://ncbi.nlm.nih.gov/pubmed/21576382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102477 |
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